PMP70 Polyclonal Antibody
Peroxisomes are single membrane organelles which are involved with many important biochemical pathways and are found in almost all eukaryotic cells. Various toxins including, phenols, alcohols, and aldehydes are targeted for modification by peroxisomes. Long chain fatty acid metabolism via beta-oxidation is also mediated by this organelle. Loss of peroxisomal functions may result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsum's disease. Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome. This protein is induced by treatment with hypolipidemic agents in parallel with peroxisome proliferation and stimulation of the peroxisomal beta-oxidation enzymes.
PMP70 Polyclonal Antibody (product # 89911) is an excellent marker for peroxisomes. It detects peroxisomal membrane protein 70 (PMP70) from mouse tissues.
PMP70 Polyclonal Antibody has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~70 kDa protein representing PMP70 from peroxisome-enriched fractions from L cells.
PMP70 Polyclonal Antibody immunizing peptide corresponds to amino acid residues 644-659 from rat PMP70. This sequence is completely conserved in mouse PMP70 and differs from human PMP70 by a single amino acid substitution.
Storage: -20C, Avoid Freeze/Thaw Cycles
Applications: Western Blotting, 1:500 dilution
Figure 1. Peroxisome enrichment from tissue.
Liver and kidney tissues (300 mg each) were processed using the Peroxisome Enrichment Kit for Tissue. Total lysate and isolated peroxisomes were analyzed by Western blotting for PMP70, a peroxisomal membrane protein marker.
| Cat.# | 製品名 | 容 量 | 価格 |
| 89911 | PMP70 Polyclonal Antibody (Anti-peroxisomal membrane protein 70) Organelle target: Peroxisome 50 µg of epitope affinity purified rabbit IgG (1 mg/ml) in PBS containing 1 mg/ml BSA and 0.05% sodium azide. |
50 µg | 販売終了 |
