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Pierce Catalog

Human Pan TCR gamma/delta Antibodies

T細胞レセプター（TCR）はTリンパ球の表面に発現して抗原と主要組織適合抗原（MHC）を共に結合する膜結合型の糖タンパク質です。この糖タンパク質を介して、抗原を認識して免疫応答を行います。TCRの構造は抗体に類似しており、抗原に結合する可変部位と定常部位からなります。Ｔ細胞はTCRにより他の白血球と区別され、また分化の段階によりＴ細胞表面抗原も異なります。免疫応答を促進するヘルパーT細胞と細胞障害作用を示すキラーT細胞の表面にはα鎖とβ鎖が会合してT細胞受容体を構成します。このαβ会合体を有するT細胞群はヒト末梢血の成熟T細胞全体の90-99％を占めます。このうち60％がヘルパーT, 30％がキラーT細胞とされています。一方で未成熟なT細胞表面にはγδ会合体が発現し、ヒト末梢血のリンパ球（PBL）の0.2-10％を占めます。このうち50-70％がVγ2遺伝子とVδ2遺伝子を発現する亜集団を占めます。

  • Species: Human
  • Type: MAb or FITC MAb
  • Format: Frozen liquid
  • Formulation: PBS with 0.5% BSA, 0.1% sodium azide and glycerol (FITC MAb)
  • Antigen: Pan TCR gamma delta
  • Antibody Host: Mouse
  • Clone #: 5A6.E9 (TCR d1)
  • Isotype: Mouse IgG1

参考文献

  1. Falini, B., et al. (1989). Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues. J. Immunol. 143, 2480-2488.
  2. Mincheva-Nilsson, L., et al. (1997). Gamma delta T cells of human early pregnancy decidua: evidence for local proliferation, phenotype heterogeneity, and extra thymic differentiation. J. Immunol. 159, 3266-3277.
  3. Rovere, P., et al. (1996). CD95 engagement releases calcium from intracellular stores of long term activated, apoptosis-prone gamma delta T cells. J. Immunol. 156, 4631-4637.
  4. Macon, W.R., et al. (1998). T-cell subset analysis of peripheral T-cell lymphocytes by paraffin section immunohistology and correlation of CD4/CD8 results with flow cytometry. Am. J. Clin. Pathol. 109, 610-617.
  5. Halstensen, T.S., et al. (1989). Intraepithelial T-cells of the TCRgamma/delta +CD8- and Vdelta/Jgamma+ phenotypes are increased in coeliac disease. Scand. J. Immunol. 30, 665-672.
  6. Seko, Y., et al. (1995). Restricted usage of T cell receptor V alpha-V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy. J. Clin. Invest. 96, 1035-1041.
  7. Band, H., et al. (1987). Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit. Science 238, 682-684.
  8. Poccia, F., et al. (1996). Peripheral V gamma9/Vd delta T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J. Immunol. 157, 449-461.
  9. Li, B., et al. (1996). Disease-specific changes in gamma delta T cell repertoire and function in patients with pulmonary tuberculosis. J. Immunol. 157, 4222-4229.
  10. Malkovsky, M., et al. (1992). Are gamma delta T cells important for the elimination of virus-infected cells? J. Med. Primatol. 21, 113-118.
  11. Satoh, M. et al. (1996). Cytotoxic gamma delta or alpha beta T cells with a natural killer cell marker, CD56, induced from human peripheral blood lymphocytes by a combination of IL-12 and IL-2. J. Immunol. 157, 3886-3892.
製品情報
Cat # 製　品　名 容量 価格 MSDS
TCR1061 Human Pan TCR gamma/delta MAb (clone 5A6.E9) 200 µg ¥53,000 BID-P203
TCR2061 Human Pan TCR gamma/delta FITC MAb (clone 5A6.E9) 200 tests ¥64,000 BID-P203