Ｔ細胞受容体抗体について
T Cell Receptors
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome (ref2). Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5).
T Cell and TCR Diversity
Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders (ref3). Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity (refs1,4).
TCR-specific Antibodies
The Thermo Scientific T cell receptor offering includes pan alphabeta and pan gammadelta antibodies as well as V alpha-, V beta-, V delta-, V gamma-, Beta F1-, Alpha F1-, and C gamma-specific antibodies. All antibodies have been QC-tested for use in flow cytometry and/or immunohistochemistry. Most clones are available in purified and FITC-labeled formats.
| Product | Clone # | Specificity | Format | Price | MSDS |
| TCR1061 | 5A6.E91 | Pan TCR gamma delta | Purified | ¥53,000 | BID-P203 |
| TCR2061 | 5A6.E91 | Pan TCR gamma delta | FITC-labeled | ¥64,000 | BID-P203 |
| TCR1145 | 3A8 | Alpha F1 | Purified | ¥54,000 | BID-P203 |
| TCR1151 | 8A3 | Beta F1 | Purified | ¥54,000 | BID-P203 |
| TCR1055 | TS-1 | Delta TCS1 | Purified | ¥55,000 | BID-P203 |
| TCR2055 | TS-1 | Delta TCS1 | FITC-labeled | ¥63,000 | BID-P203 |
| TCR1153 | gamma 3.20 | C gamma M1 | Purified | ¥55,000 | BID-P203 |
| TCR1663 | F1 | V alpha 2 | Purified | ¥56,000 | BID-P203 |
| TCR2663 | F1 | V alpha 2 | FITC-labeled | ¥62,000 | BID-P203 |
| TCR1764 | 6D6.6 | V alpha 12.1 | Purified | ¥56,000 | BID-P203 |
| TCR2764 | 6D6.6 | V alpha 12.1 | FITC-labeled | ¥63,000 | BID-P203 |
| TCR2740 | 8F10 | V beta 3.1 | FITC-labeled | ¥62,000 | BID-P203 |
| TCR1642 | 1C1 | V beta 5a | Purified | ¥55,000 | BID-P203 |
| TCR2642 | 1C1 | V beta 5a | FITC-labeled | ¥63,000 | BID-P203 |
| TCR1645 | W112 | V beta 5b | Purified | ¥54,000 | BID-P203 |
| TCR2645 | W112 | V beta 5b | FITC-labeled | ¥63,000 | BID-P203 |
| TCR1657 | OT145 | V beta 6.7 | Purified | 販売終了 | BID-P203 |
| TCR2657 | OT145 | V beta 6.7 | FITC-labeled | 販売終了 | BID-P203 |
| TCR1648 | I6G8 | V beta 8a | Purified | ¥55,000 | BID-P203 |
| TCR2648 | I6G8 | V beta 8a | FITC-labeled | ¥63,000 | BID-P203 |
| TCR1750 | MX-6 | V beta 8b | Purified | ¥56,000 | BID-P203 |
| TCR2750 | MX-6 | V beta 8b | FITC-labeled | ¥63,000 | BID-P203 |
| TCR1654 | S511 | V beta 12 | Purified | ¥56,000 | BID-P203 |
| TCR2654 | S511 | V beta 12 | FITC-labeled | ¥62,000 | BID-P203 |
| TCR1730 | TS8.2 | V delta 1 | Purified | ¥56,000 | BID-P203 |
| TCR2730 | TS8.2 | V delta 1 | FITC-labeled | ¥63,000 | BID-P203 |
| TCR1732 | 15D | V delta 2 | Purified | ¥54,000 | BID-P203 |
| TCR2732 | 15D | V delta 2 | FITC-labeled | ¥62,000 | BID-P203 |
| TCR1720 | 7A5 | V gamma 9 | Purified | ¥55,000 | BID-P203 |
| TCR2720 | 7A5 | V gamma 9 | FITC-labeled | ¥64,000 | BID-P203 |
Related Products
- Endogen ELISA Kits and Reagents for various cytokines, chemokines and growth factors, including IFN gamma, TNF alpha and IL-6.
- SearchLight Array Technology is a platform for multiplex chemiluminescent ELISA. Several 4- to 9-plex kits are available, as well as custom configurations and a sample testing service.
- ExcelArray Antibody Sandwich Microarrays are glass slide arrays for fluorescent measurement of 12 different analytes in 10 samples per slide. Convenient kits of popular combinations of analytes are available, as well as a slide-reading service.
参考文献
- Girardi, M. (2006). Immunosurveillance and immunoregulation by gamma-delta T cells. J. Invest. Dermatol. 126(1): 25-31.
- Sundberg, E.J., et al. (2007). TCR recognition of peptide/MHC class II complexes and superantigens. Semin. Immunol. 19(4): 262-271.
- Brooks, E.G., et al. (1993). Human T-cell receptor (TCR) α/β+ CD4- CD8- T cells express oligoclonal TCRs, share junctional motifs across TCR Vβ-gene families, and phenotypically resemble memory T cells. Proc. Natl. Acad. Sci. 90: 11787-11791.
- Percival, S.S., et al. (2008). Bioactive food components that enhance gammadelta T cell function may play a role in cancer prevention. J Nutr. 138(1): 1-4.
- Adelman, M.K., et al. (2007). Natural and autoantibodies to human T-cell receptor Vbeta segments : potential roles in immunomodulation. Crit. Rev. Immunol. 27(3): 221-232.
T細胞受容体抗体
- Ｔ細胞受容体抗体について
- Human Pan TCR alpha/beta Antibody
- Human Pan TCR gamma/delta Antibody
- Human TCR alpha F1 Antibody
- Human TCR beta F1 Antibody
- Human TCR C gamma M1 Antibody
- Human TCR delta TCS1 Antibody
- Human TCR V alpha 12.1 Antibody
- Human TCR V alpha 2 Antibody
- Human TCR V beta 12 Antibody
- Human TCR V beta 3.1 Antibody
- Human TCR V beta 5(a) Antibody
- Human TCR V beta 5(b) Antibody
- Human TCR V beta 6.7 Antibody
- Human TCR V beta 8(a) Antibody
- Human TCR V beta 8(b) Antibody
- Human TCR V delta 1 Antibodiy
- Human TCR V delta 2 Antibody
- Human TCR V gamma 9 Antibody
