Cytotoxicity & Apoptosis

Decrease in cell number, mitochondrial membrane potential changes, increase in membrane permeability, oxidative stress, and increase in the size of lysosomes (phospholipidosis) are some of the hallmarks of cytotoxcity. Different cell death mechanisms, including necrosis and apoptosis, are important cellular states and/or actions, with particular distinct characteristic responses and phenotypes. Activation of caspases, disruption of mitochondrial membrane potential, and nuclear condensation are some of the several markers of apoptosis. High content screening assays enable researchers to monitor and correlate multiple cellular parameters simultaneously, and thus increase the predictive power of drug toxicity.

Cytotoxicity & Apoptosis Reagents