Inflammation & Cell Stress
In response to environmental or cellular stresses, cells initiate a program of gene expression either to cope with the stress by inducing repair mechanisms or to mark the cell for apoptosis leading to cell death. This cellular stress response is a universal mechanism of extraordinary physiological/pathophysiological significance. Compromising the integrity of lipid, protein, DNA, redox status, cell cycle control, protein folding, or any one of many other events can elicit a new program of gene expression that can induce a repair process. Common stress-inducible genes include p53, JNK, AP-1, NF-kappaB, MAPK. The stressed endoplasmic reticulum (ER) responds to misfolded proteins via the unfolded protein response pathway involving ER resident transmembrane kinases and chaperones.
Reagents for Cell Stress Study
- BrdU and Ki67 Cell Proliferation Kit
- c-Jun Activation Kit
- Caspase 3 Activation Kit
- Caspase 9 Activation Kit
- Cell Motility Reagent Kit
- Cell Spreading Reagent Kit
- CHOP/GADD153 Detection Kit
- COX-2 Activation Kit
- Cytoskeletal Rearrangement Kit
- ERK MAPK Activation Kit
- Heme Oxygenase 1 Activation Kit
- Heme Oxygenase 1 and Phospho-p38 Activation Kit
- HIF-1 alpha, Phospho-CREB, FOXO3a
- Hsp27 and Phospho-Hsp27 Detection Kit
- Hsp60 and Hsp90-beta Detection Kit
- Hsp70 and Hsp90-alpha Detection Kit
- Immunophilin FKBP52 Detection Kit
- iNOS Activation Kit
- MnSOD Induction Kit
- MnSOD and Phospho-H2AX Induction Kit
- NFAT Activation Kit
- NFkB Activation Kit
- NFkB and c-Jun Activation Kit
- Oxidative Stress 1 Reagent Kit
- p38 MAPK Activation Kit
- p53 and p21 Detection Kit
- Phospho-4E-BP1 Detection Kit
- Phospho-JNK Detection Kit
- Phospho-mTOR Activation Kit
- Phospho-p53 (ser15) and p53 Detection Kit
- Phospho-S6 Detection Kit
- Stat1 Activation Kit
- Stat2 Activation Kit
- Stat3 Activation Kit
